Glioblastoma cell populations with distinct oncogenic programs release podoplanin as procoagulant extracellular vesicles.

ABSTRACT: Vascular anomalies, including local and peripheral thrombosis, are a hallmark of glioblastoma (GBM) and an aftermath of deregulation of the cancer cell genome and epigenome. Although the molecular effectors of these changes are poorly understood, the upregulation of podoplanin (PDPN) by cancer cells has recently been linked to an increased risk for venous thromboembolism (VTE) in GBM patients. Therefore, regulation of this platelet-activating protein by transforming events in cancer cells is of considerable interest. We used single-cell and bulk transcriptome data mining, as well as cellular and xenograft models in mice, to analyze the nature of cells expressing PDPN, as well as their impact on the activation of the coagulation system and platelets. We report that PDPN is expressed by dist

SUBMITTER: Tawil N 

PROVIDER: S-EPMC7993100 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature