Anticholinergic drug burden according to the anticholinergic drug scale and the German anticholinergic burden and their impact on cognitive function in multimorbid elderly German people: a multicentre observational study.

ABSTRACT:

Objectives

The aims of our study were to examine the anticholinergic drug use and to assess the association between anticholinergic burden and cognitive function in the multimorbid elderly patients of the MultiCare cohort.

Setting

MultiCare was conducted as a longitudinal cohort study in primary care, located in eight different study centres in Germany.

Participants

3189 patients (59.3% female).

Primary and secondary outcome measures

Baseline data were used for the following analyses. Drugs were classified according to the well-established anticholinergic drug scale (ADS) and the recently published German anticholinergic burden (German ACB). Cognitive function was measured using a letter digit substitution test (LDST) and a mixed-effect multivariate linear regr

SUBMITTER: Kruger C 

PROVIDER: S-EPMC7993236 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature