Therapeutic Opportunities for Intestinal Angioectasia- Targeting PPARγ and Oxidative Stress.

ABSTRACT: Recurrent and acute bleeding from intestinal tract angioectasia (AEC) presents a major challenge for clinical intervention. Current treatments are empiric, with frequent poor clinical outcomes. Improvements in understanding the pathophysiology of these lesions will help guide treatment. Using data from the US Food and Drug Administration (FDA)'s Adverse Event Reporting System (FAERS), we analyzed 12 million patient reports to identify drugs inversely correlated with gastrointestinal bleeding and potentially limiting AEC severity. FAERS analysis revealed that drugs used in patients with diabetes and those targeting PPARγ-related mechanisms were associated with decreased AEC phenotypes (P < 0.0001). Electronic health records (EHRs) at University of Cincinnati Hospital were analyzed to valida

SUBMITTER: Sarangdhar M 

PROVIDER: S-EPMC7993272 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature