Validation of the movement disorder society criteria for the diagnosis of 4-repeat tauopathies.

ABSTRACT:

Background

The Movement Disorder Society criteria for progressive supranuclear palsy introduced the category "probable 4-repeat (4R)-tauopathy" for joint clinical diagnosis of progressive supranuclear palsy and corticobasal degeneration.

Objectives

To validate the accuracy of these clinical criteria for "probable 4R-tauopathy" to predict underlying 4R-tauopathy pathology.

Methods

Diagnostic accuracy for 4R-tauopathies according to the established criteria was estimated retrospectively in autopsy-confirmed patients with progressive supranuclear palsy and corticobasal degeneration (grouped as 4R-tauopathies), and Parkinson's disease, multiple system atrophy, and frontotemporal lobar degeneration (grouped as non-4R-tauopathies).

Results

We identified 250 cases wit

SUBMITTER: Respondek G 

PROVIDER: S-EPMC7993399 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature