New susceptibility alleles associated with severe coronary artery stenosis in the Lebanese population.

ABSTRACT:

Background

Coronary Artery Disease (CAD) is the narrowing or blockage of the coronary arteries. It is closely associated with numerous genetics and environmental factors that have been extensively evaluated in various populations. In recent studies, severe phenotypes have been strongly linked to genetic risk factors.

Methods

This study investigated the association of clinical, demographic, and genetic factors with severe coronary artery stenosis phenotypes in our population composed of 1734 individuals with severe coronary stenosis (≥ 50% in coronary vessels) and comparing them to 757 controls with no evidence of stenosis on angiography. We performed generalized linear model (GLM) genome-wide association studies to evaluate three stratification models and their associations

SUBMITTER: Wakim V 

PROVIDER: S-EPMC7993530 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature