Berberine-induced TFEB deacetylation by SIRT1 promotes autophagy in peritoneal macrophages.

ABSTRACT: Atherosclerosis is a chronic inflammatory disease that commonly affects the elderly and is characterized by vascular damage, macrophage infiltration, and plaque formation. Moreover, it increases the risk of cardiovascular disease. The pathogenesis of atherosclerosis involves an interplay between macrophage autophagy and apoptosis. A recently discovered transcription factor, transcription factor EB (TFEB) is known to activate autophagy in macrophages. Sirtuin deacetylase 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD⁺)-dependent histone deacetylase, activates several transcription factors, including TFEB. We studied the effects of berberine on the NAD⁺ synthesis pathway and interactions between SIRT1 and TFEB. We also studied the effects of berberine-induced TFEB

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC7993719 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature