Pan-cancer investigation reveals mechanistic insights of planar cell polarity gene Fuz in carcinogenesis.

ABSTRACT: The fuzzy planar cell polarity protein (Fuz) is an effector component of the planar cell polarity (PCP) signaling. Together with other core and effector proteins, the PCP pathway controls polarized cell movements. Fuz was also reported as a negative regulator of cell survival. In this study, we performed a pan-cancer survey to demonstrate the role of Fuz in multiple types of cancer. In head-neck squamous cell carcinoma and lung adenocarcinoma tumor samples, a reduction of Fuz transcript expression was detected. This coincides with the poor overall survival probabilities of these patients. We further showed that Fuz promoter hypermethylation contributes to its transcriptional downregulation. Meanwhile, we also identified a relatively higher mutation frequency at the 404^th

SUBMITTER: Chen ZS 

PROVIDER: S-EPMC7993721 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature