Slowpoke functions in circadian output cells to regulate rest:activity rhythms.

ABSTRACT: The circadian system produces ~24-hr oscillations in behavioral and physiological processes to ensure that they occur at optimal times of day and in the correct temporal order. At its core, the circadian system is composed of dedicated central clock neurons that keep time through a cell-autonomous molecular clock. To produce rhythmic behaviors, time-of-day information generated by clock neurons must be transmitted across output pathways to regulate the downstream neuronal populations that control the relevant behaviors. An understanding of the manner through which the circadian system enacts behavioral rhythms therefore requires the identification of the cells and molecules that make up the output pathways. To that end, we recently characterized the Drosophila pars intercerebralis (PI) as

SUBMITTER: Ruiz D 

PROVIDER: S-EPMC7993846 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature