Association of the host genetic factors, hypercholesterolemia and diabetes with mild influenza in an Iranian population.

ABSTRACT:

Background

Variation in host genetic factors may result in variation in the host immune response to the infection. Some chronic diseases may also affect individuals' susceptibility to infectious diseases. The aim of this study was to evaluate the association of the host genetic factors mostly involved in inflammation, as well as hypercholesterolemia and diabetes with mild flu in an Iranian population.

Methods

In this cross-sectional study, nasopharyngeal swab samples were collected from 93 patients referred to primary care centers of Markazi, Semnan, and Zanjan provinces (central Iran) due to flu-like symptoms between March 2015 and December 2018. Of these, PCR test identified 49 influenza A/H1N1 and 44 flu-negative individuals. Twelve single-nucleotide polymorphisms (SNPs)

SUBMITTER: Mehrbod P 

PROVIDER: S-EPMC7993858 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature