Mineral bone disease in autosomal dominant polycystic kidney disease.

ABSTRACT: Mice with disruption of Pkd1 in osteoblasts demonstrate reduced bone mineral density, trabecular bone volume and cortical thickness. To date, the bone phenotype in adult patients with autosomal dominant polycystic kidney disease (ADPKD) with stage I and II chronic kidney disease has not been investigated. To examine this, we characterized biochemical markers of mineral metabolism, examined bone turnover and biology, and estimated risk of fracture in patients with ADPKD. Markers of mineral metabolism were measured in 944 patients with ADPKD and other causes of kidney disease. Histomorphometry and immunohistochemistry were compared on bone biopsies from 20 patients with ADPKD with a mean eGFR of 97 ml/min/1.73m² and 17 healthy individuals. Furthermore, adults with end stage kidney

SUBMITTER: Gitomer B 

PROVIDER: S-EPMC7993988 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature