Individual differences in haemoglobin concentration influence bold fMRI functional connectivity and its correlation with cognition.

ABSTRACT: Resting-state connectivity measures the temporal coherence of the spontaneous neural activity of spatially distinct regions, and is commonly measured using BOLD-fMRI. The BOLD response follows neuronal activity, when changes in the relative concentration of oxygenated and deoxygenated haemoglobin cause fluctuations in the MRI T2* signal. Since the BOLD signal detects changes in relative concentrations of oxy/deoxy-haemoglobin, individual differences in haemoglobin levels may influence the BOLD signal-to-noise ratio in a manner independent of the degree of neural activity. In this study, we examined whether group differences in haemoglobin may confound measures of functional connectivity. We investigated whether relationships between measures of functional connectivity and cognitive perform

SUBMITTER: Ward PGD 

PROVIDER: S-EPMC7994014 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature