Progress and Pitfalls of Bacteriophage Therapy in Critical Care: A Concise Definitive Review.

ABSTRACT:

Objective

Bacterial infections caused by antibiotic-resistant pathogens are a major problem for patients requiring critical care. An approach to combat resistance is the use of bacterial viruses known as "phage therapy." This review provides a brief "clinicians guide" to phage biology and discusses recent applications in the context of common infections encountered in ICUs.

Data sources

Research articles were sourced from PubMed using search term combinations of "bacteriophages" or "phage therapy" with either "lung," "pneumonia," "bloodstream," "abdominal," "urinary tract," or "burn wound."

Study selection

Preclinical trials using animal models, case studies detailing compassionate use of phage therapy in humans, and randomized controlled trials were included.

Data

SUBMITTER: Valente L 

PROVIDER: S-EPMC7994034 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature