New Decade, Old Debate: Blocking the Cytokine Pathways in Infection-Induced Cytokine Cascade.

ABSTRACT:

Objectives

Our understanding of the immunopathogenesis of coronavirus disease 2019 is evolving; however, a "cytokine storm" has been implicated. Ongoing clinical trials are evaluating the value of anticytokine therapies to treat patients with coronavirus disease 2019. This review summarizes the existing literature evaluating the efficacy and safety of anticytokine therapy to tackle the dysregulated immune response to infectious pathogens, discusses potential reasons for failure, applicability to coronavirus disease 2019, and future direction.

Data sources

Medline, PubMed, ClinicalTrials.gov, and media reports.

Study selection

The studies were included by author consensus.

Data extraction

Data were selected for inclusion after reviewing each study by author cons

SUBMITTER: Rizvi MS 

PROVIDER: S-EPMC7994048 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature