RBM23 Drives Hepatocellular Carcinoma by Activating NF-κB Signaling Pathway.

ABSTRACT:

Purpose

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, and angiogenesis has been proven to be significantly involved in its progression. However, the molecular mechanism underlying HCC angiogenesis has not been well researched. In this study, RNA Binding Motif Protein 23 (RBM23) was identified as a novel proangiogenic factor in HCC cell lines and tissues.

Materials and methods

Firstly, we analyzed the correlation of clinical specimens. In HCC tissues, the levels of RBM23 and microvessel density (MVD) showed a strong positive correlation. Furthermore, data from related cytology experiments showed that the knockdown of RBM23 expression in HCC cells significantly inhibited the tube formation by the human vascular endothelial cells in vitro.

SUBMITTER: Han H 

PROVIDER: S-EPMC7994101 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature