Time to surgery among women treated with neoadjuvant systemic therapy and upfront surgery for breast cancer.

ABSTRACT:

Purpose

Time to surgery (TTS) is a potentially modifiable factor associated with survival after breast cancer diagnosis and can serve as a proxy for quality of oncologic care coordination. We sought to determine whether factors associated with delays in TTS vary between patients who receive neoadjuvant systemic therapy (NST) vs upfront surgery and whether the impact of these delays on overall survival (OS) varies with treatment sequence.

Methods

Women ≥ 18 years old with Stage I-III breast cancer were identified in the National Cancer Database (2004-2014). Multivariate linear regression stratified by treatment sequence (upfront surgery vs NST [neoadjuvant chemotherapy {NAC}, neoadjuvant endocrine therapy {NAE}, or both {NACE}]) was used to identify factors associated with TT

SUBMITTER: Prakash I 

PROVIDER: S-EPMC7994184 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature