Progress towards the development of a P. vivax vaccine.

ABSTRACT:

Introduction

Plasmodium vivax causes significant public health problems in endemic regions. A vaccine to prevent disease is critical, considering the rapid spread of drug-resistant parasite strains, and the development of hypnozoites in the liver with potential for relapse. A minimally effective vaccine should prevent disease and transmission while an ideal vaccine provides sterile immunity.

Areas covered

Despite decades of research, the complex life cycle, technical challenges and a lack of funding have hampered progress of P. vivax vaccine development. Here, we review the progress of potential P. vivax vaccine candidates from different stages of the parasite life cycle. We also highlight the challenges and important strategies for rational vaccine desi

SUBMITTER: De SL 

PROVIDER: S-EPMC7994195 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature