Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Reponse Exemplified by Levofloxacin.

ABSTRACT:

Purpose

Systematic comparison of analysis methods of clinical microdialysis data for impact on target-site drug exposure and response.

Methods

39 individuals received a 500 mg levofloxacin short-term infusion followed by 24-h dense sampling in plasma and microdialysate collection in interstitial space fluid (ISF). ISF concentrations were leveraged using non-compartmental (NCA) and compartmental analysis (CA) via (ii) relative recovery correction at midpoint of the collection interval (midpoint-NCA, midpoint-CA) and (ii) dialysate-based integrals of time (integral-CA). Exposure and adequacy of community-acquired pneumonia (CAP) therapy via pharmacokinetic/pharmacodynamic target-attainment (PTA) analysis were compared between approaches.

Results

Individual AUC_ISF</

SUBMITTER: Busse D 

PROVIDER: S-EPMC7994214 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature