Sodium Fluoride-18 and Radium-223 Dichloride Uptake Colocalize in Osteoblastic Mouse Xenograft Tumors.

ABSTRACT: Background: Patients with osteoblastic bone metastases are candidates for radium-223 (²²³RaCl₂) therapy and may undergo sodium fluoride-18 (¹⁸F-NaF) positron emission tomography-computed tomography imaging to identify bone lesions. ¹⁸F-NaF has been shown to predict ²²³RaCl₂ uptake, but intratumor distributions of these two agents remain unclear. In this study, the authors evaluate the spatial distribution and relative uptakes of ¹⁸F-NaF and ²²³RaCl₂ in Hu09-H3 human osteosarcoma mouse xenograft tumors at macroscopic and microscopic levels to better quantify their correlation. Materials and Methods: ¹⁸F-NaF and ²²³RaCl₂ were co-injec

SUBMITTER: Phelps TE 

PROVIDER: S-EPMC7994428 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature