EGF Induces Migration Independent of EMT or Invasion in A549 Lung Adenocarcinoma Cells.

ABSTRACT: Tumors and the tumor microenvironment produce multiple growth factors that influence cancer cell behavior via various signal transduction pathways. Growth factors, like transforming growth factor β (TGFβ) and epidermal growth factor (EGF), have been shown to induce proliferation, migration, and invasion in different cell models. Both factors are frequently overexpressed in cancer and will often act in combination. Although both factors are being used as rational targets in clinical oncology, the similarities and differences of their contributions to cancer cell migration and invasion are not fully understood. Here we compared the impact of treating A549 lung adenocarcinoma cells with TGFβ, EGF, and both in combination by applying videomicroscopy, functional assays, immunoblotting, real-tim

SUBMITTER: Schelch K 

PROVIDER: S-EPMC7994520 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature