Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation.

ABSTRACT: Disturbed blood flow has been increasingly recognized for its critical role in platelet aggregation and thrombosis. Microfluidics with hump shaped contractions have been developed to mimic microvascular stenosis and recapitulate the prothrombotic effect of flow disturbance. However the physical determinants of microfluidic hemodynamics are not completely defined. Here, we report a refined computational fluid dynamics (CFD) simulation approach to map the shear rate (γ) and wall shear stress (τ) distribution in the stenotic region at high accuracy. Using ultra-fine meshing with sensitivity verification, our CFD results show that the stenosis level (S) is dominant over the bulk shear rate (γ₀) and contraction angle (α) in determining γ and τ distribution at stenosis. In contrast, α

SUBMITTER: Zhao YC 

PROVIDER: S-EPMC7994556 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature