Mapping the orbitofrontal cortex using temporal fluctuations in cerebral blood flow.

ABSTRACT:

Introduction

The orbitofrontal cortex (OFC) is involved in diverse cognitive and behavioral processes including incentive valuation, decision-making, and reinforcement learning. Anatomic and cytoarchitectonic studies divide the OFC along both medial-lateral and rostral-caudal axes. OFC regions diverge in structure and function, assessed in vivo using white matter tractography and blood oxygenation level-dependent (BOLD) MRI, respectively. However, interpretation of T₂ *-weighted BOLD is limited by susceptibility artifacts in the inferior frontal lobes, with the spatial pattern of these artifacts frequently assuming the geometry of OFC organization. Here, we utilize a novel perfusion-weighted arterial spin labeling (ASL) functional connectivity approach, which is minimall

SUBMITTER: Petersen KJ 

PROVIDER: S-EPMC7994685 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature