The Association between Neprilysin gene polymorphisms and Alzheimer's disease in Tibetan population.

ABSTRACT:

Objectives

Alzheimer's disease (AD) is a well-known neurodegenerative disease, of which the hallmark is the disposition of β-amyloid (Aβ) in the form of plaque in the brain. Neprilysin (NEP) is the major enzyme to degrade Aβ and prevent accumulation of Aβ. The present study was undertaken to elucidate the correlation between the NEP gene polymorphisms and AD in Chinese Tibetan population.

Methods

Ninety-nine sporadic AD Tibetan patients and 113 healthy Tibetan controls were enrolled in this study. The genotype frequencies and allele frequencies of multiple NEP gene loci were analyzed using the case-control association analysis.

Results

No significant correlation was found between polymorphisms of NEP gene loci (rs9829757, rs1816558, rs6776185, rs3736187, rs701109, rs9

SUBMITTER: Chen S 

PROVIDER: S-EPMC7994707 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature