Prognostic Alternative mRNA Splicing in Adrenocortical Carcinoma.

ABSTRACT:

Background

This paper aims to identify alternative RNA splicing landscape and its prognostic value in adrenocortical carcinoma.

Methods

The alternative splicing events data with corresponding clinical information data of 79 ACC patients were obtained from the Cancer Genome Atlas and SpliceSeq package. Prognosis-associated AS events by using univariate Cox regression analysis were selected. Gene functional enrichment analysis demonstrated the potential pathways enriched by survival-associated AS. Prognosis-related splicing events were submitted to develop moderate predictors using Lasso regression model.

Results

One thousand five survival-associated alternative splicing events were identified. The prognostic genes included ATXN2L, MEIS1, IKBKB, COX4I1<

SUBMITTER: Liang W 

PROVIDER: S-EPMC7994755 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature