Ambient PM_2.5 species and ultrafine particle exposure and their differential metabolomic signatures.

ABSTRACT:

Background

The metabolomic signatures of short- and long-term exposure to PM_2.5 have been reported and linked to inflammation and oxidative stress. However, little is known about the relative contribution of the specific PM_2.5 species (hence sources) that drive these metabolomic signatures.

Objectives

We aimed to determine the relative contribution of the different species of PM_2.5 exposure to the perturbed metabolic pathways related to changes in the plasma metabolome.

Methods

We performed mass-spectrometry based metabolomic profiling of plasma samples among men from the Normative Aging Study to identify metabolic pathways associated with PM_2.5 species. The exposure windows included short-term (one, seven-, and thirty-day m

SUBMITTER: Nassan FL 

PROVIDER: S-EPMC7994935 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature