Mid-regional pro-atrial natriuretic peptide independently predicts short-term mortality in COVID-19.

ABSTRACT:

Background

Mid-regional pro-atrial natriuretic peptide (MR-proANP) is a strong prognostic marker in several inflammatory, respiratory and cardiovascular conditions, but has not been studied in COVID-19 yet.

Methods

This prospective, observational study of patients with COVID-19 infection was conducted from 6 June to 26 November 2020 in different wards of a tertiary hospital. MR-proANP, N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin I levels on admission were collected and tested for their association with disease severity and 28-day mortality.

Results

A total of 213 eligible patients with COVID-19 were included in the final analyses of whom 13.2% (n = 28) died within 28 days. Median levels of MR-proANP at admission were signif

SUBMITTER: Kaufmann CC 

PROVIDER: S-EPMC7995001 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature