Ultraefficiently Calming Cytokine Storm Using Ti₃C₂T _x MXene.

ABSTRACT: During the global outbreak of COVID-19 pandemic, "cytokine storm" conditions are regarded as the fatal step resulting in most mortality. Hemoperfusion is widely used to remove cytokines from the blood of severely ill patients to prevent uncontrolled inflammation induced by a cytokine storm. This article discoveres, for the first time, that 2D Ti₃C₂T _x MXene sheet demonstrates an ultrahigh removal capability for typical cytokine interleukin-6. In particular, MXene shows a 13.4 times higher removal efficiency over traditional activated carbon absorbents. Molecular-level investigations reveal that MXene exhibits a strong chemisorption mechanism for immobilizing cytokine interleukin-6 molecules, which is different from activated carbon absorbents. MXene

SUBMITTER: Wang T 

PROVIDER: S-EPMC7995020 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature