Hazards of diethyl phthalate (DEP) exposure: A systematic review of animal toxicology studies.

ABSTRACT:

Background

Diethyl phthalate (DEP) is widely used in many commercially available products including plastics and personal care products. DEP has generally not been found to share the antiandrogenic mode of action that is common among other types of phthalates, but there is emerging evidence that DEP may be associated with other types of health effects.

Objective

To inform chemical risk assessment, we performed a systematic review to identify and characterize outcomes within six broad hazard categories (male reproductive, female reproductive, developmental, liver, kidney, and cancer) following exposure of nonhuman mammalian animals to DEP or its primary metabolite, monoethyl phthalate (MEP).

Methods

A literature search was conducted in online scientific databases (PubM

SUBMITTER: Weaver JA 

PROVIDER: S-EPMC7995140 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature