Annexin A3 is necessary for parallel artery-vein alignment in the mouse retina.

ABSTRACT:

Background

Annexin A3 (Anxa3) is a member of the calcium-regulated, cell membrane-binding family of annexin proteins. We previously confirmed that Anxa3 is expressed in the endothelial lineage in vertebrates and that loss of anxa3 in Xenopus laevis leads to embryonic blood vessel defects. However, the biological function of Anxa3 in mammals is completely unknown. In order to investigate Anxa3 vascular function in mammals, we generated an endothelial cell-specific Anxa3 conditional knockout mouse model (Anxa3^f/f ;Tie2-Cre).

Results

Anxa3^f/f ;Tie2-Cre mice are born at Mendelian ratios and display morphologically normal blood vessels during development. However, loss of Anxa3 leads to artery-vein (AV) misalignment characterized by atypical AV crossovers in

SUBMITTER: Huang K 

PROVIDER: S-EPMC7995330 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature