Dataset Information

Evaluation of the accuracy of an electronic point-of-care analyzer to quantify blood creatinine concentration in goats.

ABSTRACT:

Background

There are no commercially available handheld blood creatinine analyzers validated in goats.

Objectives

The objective of the study was to validate the accuracy of a handheld point-of-care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondary objective was to compare this POC against a chemistry analyzer to classify goats as normal or having mild or moderate azotemia.

Animals

Sixty-three goats admitted to a referral hospital.

Methods

Cross-sectional study. Venous blood was obtained, and creatinine concentration was measured by the POC in duplicate. Plasma was submitted for creatinine determination via the chemistry analyzer (gold standard).

Results

A total of 101 blood samples were collected from 63 goats. There was high repeatability for creatinine concentrations obtained by the POC (adjusted R² = .97, P < .0001). Correlation of POC concentrations with those reported by the chemistry analyzer was moderate (adjusted R² = .57, P < .0001). When correctly categorizing goats with mild azotemia, the POC demonstrated a sensitivity of 73.3% and a specificity of 88.3%. For moderate to severe azotemia, the POC had a sensitivity of 75.0% and specificity of 97.5%.

Conclusion and clinical importance

The Nova StatSensor POC provided above average accuracy for measuring blood creatinine concentration in goats compared with the gold standard test.

SUBMITTER: Boileau MJ

PROVIDER: S-EPMC7995365 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Evaluation of the accuracy of an electronic point-of-care analyzer to quantify blood creatinine concentration in goats.

Boileau Melanie J MJ Wagner Leslie L Taylor Jared D JD

Journal of veterinary internal medicine 20210224 2

<h4>Background</h4>There are no commercially available handheld blood creatinine analyzers validated in goats.<h4>Objectives</h4>The objective of the study was to validate the accuracy of a handheld point-of-care (POC) analyzer (Nova StatSensor) for quantifying blood creatinine concentration in goats. A secondary objective was to compare this POC against a chemistry analyzer to classify goats as normal or having mild or moderate azotemia.<h4>Animals</h4>Sixty-three goats admitted to a referral h ...[more]

PMID: 33625770

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Project description:BackgroundAnemia is one of the most impactful nutrient deficiencies in the world and disproportionately affects children in low-resource settings. Point-of-care devices (PoCDs) measuring blood hemoglobin (Hb) are widely used in such settings to screen for anemia due to their low cost, speed, and convenience. Here we present the first iteration of Aptus, a new PoCD which measures Hb and hematocrit (HCT).AimTo evaluate the accuracy of Aptus and HemoCue® Hb 301 against an automated hematology analyzer (Medonic®) in Gambian children aged 6-35 months and the Aptus' usage in the field.MethodsAptus, HemoCue® and Medonic® were compared using venous blood (n = 180), and Aptus and HemoCue® additionally using capillary blood (n = 506). Agreement was estimated using Bland-Altman analysis and Lin's concordance. Usage was assessed by error occurrence and user experience.ResultsMean Hb values in venous blood did not significantly differ between Aptus and HemoCue® (10.44±1.05 vs 10.56±0.93g/dl, p>0.05), but both measured higher Hb concentrations than Medonic® (9.75±0.99g/dl, p<0.0001). Lin's coefficient between Aptus and Medonic® was rc = 0.548, between HemoCue® and Medonic® rc = 0.636. Mean bias between the PoCDs venous measurements was -0.11g/dl with limits of agreement (LoA) -1.63 and 1.40g/dl. The bias was larger for the comparisons between the Medonic® and both Aptus (0.69g/dl, LoA 0.92 and 2.31g/dl) and HemoCue® (0.81g/dl, LoA 0.17 and 1.78g/dl). ROC curves showed an AUC of 0.933 in HemoCue® and 0.799 in Aptus. Capillary Hb was higher with Aptus than HemoCue® (10.33±1.11g/dl vs 10.01±1.07g/dl, p<0.0001). Mean bias was 0.32g/dl with LoA of -1.91 and 2.54g/dl. Aptus' usage proved intuitive, yet time-to-results and cuvettes could be improved.ConclusionBoth PoCDs showed a relatively limited bias but large LoA. Aptus and HemoCue® showed similar accuracy, while both overestimated Hb levels. Aptus showed promise, with its operation unimpaired by field conditions as well as being able to show HCT values.

Dataset Information

Evaluation of the accuracy of an electronic point-of-care analyzer to quantify blood creatinine concentration in goats.

Background

Objectives

Animals

Methods

Results

Conclusion and clinical importance

Publications

Evaluation of the accuracy of an electronic point-of-care analyzer to quantify blood creatinine concentration in goats.

Similar Datasets

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