Biological variation of major gut-derived uremic toxins in the serum of healthy adult cats.

ABSTRACT:

Background

Biological variation of serum indoxyl sulfate (IS), p-cresol sulfate (pCS), and trimethylamine-n-oxide (TMAO) concentrations in cats is unknown.

Objectives

To determine short- and medium-term biological variation, index of individuality (II), and reference change values for serum IS, pCS, and TMAO concentrations in healthy adult cats. To determine the effect of feeding on serum concentrations.

Animals

Twelve healthy adult cats.

Methods

Prospective, cohort study. Seven serum samples over a 12-hour period (short-term) and 5 serum samples over a 19-day period (medium-term) were collected. Serum concentrations of total IS, pCS, and TMAO were measured every 2 hours in a 12-hour period (hours 0-12) after a meal in 9 cats and compared to concentrations in a

SUBMITTER: Summers S 

PROVIDER: S-EPMC7995407 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature