Symmetric dimethylarginine and creatinine concentrations in serum of healthy draft horses.

ABSTRACT:

Background

Symmetric dimethylarginine (SDMA) is considered a more sensitive indirect estimate of glomerular filtration rate (GFR) than creatinine (Cr). Symmetric dimethylarginine is not affected by sex or muscle mass in small animals.

Objectives

To validate a commercial SDMA immunoassay (IA) for equine serum; to compare SDMA and Cr in cohorts of draft horse breeds; and to assess effects of age, sex, and breed.

Animals

One hundred and sixty-five healthy draft horses (0.5-16 years), including 63 Percherons, 52 Clydesdales, and 50 Belgians.

Methods

Cross-sectional study. The SDMA IA was validated for equine serum by comparison to liquid chromatography-mass spectroscopy (LC-MS) results and other methods. Symmetric dimethylarginine and Cr were compared by analysis o

SUBMITTER: Schott HC 

PROVIDER: S-EPMC7995414 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature