Light chain myeloma and detection of free light chains in serum and urine of dogs and cats.

ABSTRACT:

Background

Detection of free light chains (fLC) in animals relies on protein electrophoresis or the Bence-Jones protein test on urine.

Objective

To describe the detection of both serum fLC (sfLC) and urine fLC (ufLC) in 8 dogs and 2 cats using a commercially available human immunofixation (IF) kit.

Animals

Archived serum or urine samples from 27 dogs and 2 cats submitted to the Colorado State University Veterinary Diagnostic Laboratory for routine diagnostics.

Methods

Retrospective study evaluating the presence of fLC in dogs and cats using agarose gel electrophoresis and routine and fLC IF performed on serum and urine. The performance of the fLC IF reagents was evaluated using samples characterized by routine IF, tandem mass spectrometry, and a combination of

SUBMITTER: Harris RA 

PROVIDER: S-EPMC7995444 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature