OncoGEMINI: software for investigating tumor variants from multiple biopsies with integrated cancer annotations.

ABSTRACT:

Background

DNA sequencing has unveiled extensive tumor heterogeneity in several different cancer types, with many exhibiting diverse subclonal populations. Identifying and tracing mutations throughout the expansion and progression of a tumor represents a significant challenge. Furthermore, prioritizing the subset of such mutations most likely to contribute to tumor evolution or that could serve as potential therapeutic targets represents an ongoing problem.

Results

Here, we describe OncoGEMINI, a new tool designed for exploring the complex patterns and trajectory of somatic and inherited variation observed in heterogeneous tumors biopsied over the course of treatment. This is accomplished by creating a searchable database of variants that includes tumor sampling time points

SUBMITTER: Nicholas TJ 

PROVIDER: S-EPMC7995589 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature