H3K27 modifiers regulate lifespan in C. elegans in a context-dependent manner.

ABSTRACT:

Background

Evidence of global heterochromatin decay and aberrant gene expression in models of physiological and premature ageing have long supported the "heterochromatin loss theory of ageing", which proposes that ageing is aetiologically linked to, and accompanied by, a progressive, generalised loss of repressive epigenetic signatures. However, the remarkable plasticity of chromatin conformation suggests that the re-establishment of such marks could potentially revert the transcriptomic architecture of animal cells to a "younger" state, promoting longevity and healthspan. To expand our understanding of the ageing process and its connection to chromatin biology, we screened an RNAi library of chromatin-associated factors for increased longevity phenotypes.

Results

We identif

SUBMITTER: Guillermo ARR 

PROVIDER: S-EPMC7995591 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature