Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs.

ABSTRACT: Extensive hierarchical yet highly reciprocal interactions among cortical areas are fundamental for information processing. However, connectivity rules governing the specificity of such corticocortical connections, and top-down feedback projections in particular, are poorly understood. We analyze synaptic strength from functionally relevant brain areas to diverse neuronal types in the primary somatosensory cortex (S1). Long-range projections from different areas preferentially engage specific sets of GABAergic neurons in S1. Projections from other somatosensory cortices strongly recruit parvalbumin (PV)-positive GABAergic neurons and lead to PV neuron-mediated feedforward inhibition of pyramidal neurons in S1. In contrast, inputs from whisker-related primary motor cortex are biased to vasoa

SUBMITTER: Naskar S 

PROVIDER: S-EPMC7995594 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature