Hypoxia modulation by dual-drug nanoparticles for enhanced synergistic sonodynamic and starvation therapy.

ABSTRACT:

Background

Sonodynamic therapy (SDT) is an emerging non-invasive therapeutic technique. SDT-based cancer therapy strategies are presently underway, and it may be perceived as a promising approach to improve the efficiency of anti-cancer treatment. In this work, multifunctional theranostic nanoparticles (NPs) were synthesized for synergistic starvation therapy and SDT by loading glucose oxidase (GOx, termed G) and 5,10,15,20-tetrakis (4-chlorophenyl) porphyrin) Cl (T (p-Cl) PPMnCl, termed PMnC) in Poly (lactic-co-glycolic) acid (PLGA) NPs (designated as MG@P NPs).

Results

On account of the peroxidase-like activity of PMnC, MG@P NPs can catalyze hydrogen peroxide (H₂O₂) in tumor regions to produce oxygen (O₂), thus enhancing synergistic therape

SUBMITTER: Wang J 

PROVIDER: S-EPMC7995598 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature