A prospective study of type 2 diabetes, metformin use, and risk of breast cancer.

ABSTRACT:

Background

Type 2 diabetes (T2D) has been associated with increased breast cancer risk, but commonly prescribed antidiabetic medications such as metformin may reduce risk. Few studies have investigated T2D and medications together in relation to breast cancer.

Patients and methods

Data came from 44 541 Sister Study participants aged 35 to 74 years at enrollment (2003-2009) who satisfied eligibility criteria, followed through 15 September 2017. Information on time-varying, self-reported, physician-diagnosed, prevalent and incident T2D, use of antidiabetic medications, and covariates was obtained from baseline and follow-up questionnaires. Incident breast cancers were confirmed with medical records. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated.

Resu

SUBMITTER: Park YM 

PROVIDER: S-EPMC7995619 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature