Ontology highlight
ABSTRACT:
SUBMITTER: Oldham Green N
PROVIDER: S-EPMC7995657 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Oldham Green Nicole N Maniam Jayanthi J Riese Jessica J Morris Margaret J MJ Voineagu Irina I
Neurobiology of stress 20210310
Early life stress (ELS) is associated with adverse mental health outcomes including anxiety, depression and addiction-like behaviours. While ELS is known to affect the developing brain, leading to increased stress responsiveness and increased glucocorticoid levels, the molecular mechanisms underlying the detrimental effects of ELS remain incompletely characterised. Rodent models have been instrumental in beginning to uncover the molecular and cellular underpinnings of ELS. Limited nesting (LN), ...[more]