A fifty percent leucine-restricted diet reduces fat mass and improves glucose regulation.

ABSTRACT:

Background

Leucine deprivation modulates the dietary amino acid composition, reducing the fat content and improving the glucose tolerance, thus protecting the organism against obesity. However, a complete deprivation of leucine can lead to an extremely rapid fat loss in mice, accompanied by prolonged adverse effects such as weakness and mental fatigue. Therefore, in this study we aimed to seek the optimal concentration of dietary leucine that can reduce fat mass and improve the metabolism without the onset of severe effects.

Methods

To investigate whether there is a better concentration of diet leucine restriction (LR), based on the diet we conducted (A10021B), that can reduce fat mass and improve metabolism status without taking many negative effects, we fed 8 weeks old mal

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC7995702 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature