Expression and prognostic roles of PRDXs gene family in hepatocellular carcinoma.

ABSTRACT:

Background

As the fourth leading cause of cancer-related death in the world, the therapeutic effect and 5-year overall survival of hepatocellular carcinoma (HCC) are not optimistic. Previous researches indicated that the disorder of PRDXs was related to the occurrence and development of cancers.

Methods

In this study, PRDXs were found in various tumor cell lines by CCLE database analysis. The analysis results of UALCAN, HCCDB and Human Protein Atlas databases showed the expression of PRDXs mRNA and protein in HCC tissues was dysregulated. Besides, UALCAN was used to assess the correlations between PRDXs mRNA as well as methylation levels and clinical characterization.

Results

High expression of PRDX1 or low expression of PRDX2/3 suggested poor prognosis for HCC patien

SUBMITTER: Xu M 

PROVIDER: S-EPMC7995729 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature