Pseudomonas aeruginosa prioritizes detoxification of hydrogen peroxide over nitric oxide.

ABSTRACT:

Objective

Bacteria are exposed to multiple concurrent antimicrobial stressors within phagosomes. Among the antimicrobials produced, hydrogen peroxide and nitric oxide are two of the most deleterious products. In a previous study, we discovered that when faced with both stressors simultaneously, Escherichia coli prioritized detoxification of hydrogen peroxide over nitric oxide. In this study, we investigated whether such a process was conserved in another bacterium, Pseudomonas aeruginosa.

Results

P. aeruginosa prioritized hydrogen peroxide detoxification in a dose-dependent manner. Specifically, hydrogen peroxide detoxification was unperturbed by the presence of nitric oxide, whereas larger doses of hydrogen peroxide produced longer delays in nitric oxide detoxification. Com

SUBMITTER: Sivaloganathan DM 

PROVIDER: S-EPMC7995768 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature