Association of MAPT H1 subhaplotypes with neuropathology of lewy body disease.

ABSTRACT:

Background

Genetic variation at the microtubule-associated protein tau locus is associated with clinical parkinsonism. However, it is unclear as to whether microtubule-associated protein tau H1 subhaplotypes are associated with the burden of neuropathological features of Lewy body disease.

Objectives

To evaluate associations of microtubule-associated protein tau haplotypes with severity of Lewy body pathology and markers of SN neuronal loss in Lewy body disease cases.

Methods

Five hundred eighty-five autopsy-confirmed Lewy body disease cases were included. Six microtubule-associated protein tau variants (rs1467967, rs242557, rs3785883, rs2471738, rs8070723, and rs7521) were genotyped to define common microtubule-associated protein tau haplotypes. Lewy body counts were

SUBMITTER: Heckman MG 

PROVIDER: S-EPMC7996001 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature