Physiopathology of ischemic stroke and its modulation using memantine: evidence from preclinical stroke.

ABSTRACT: Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the brain. In this disease, two different damage areas are identifying: the lesion core, in which cells quickly die; and the penumbra (surrounding the lesion core), in which cells are functionally weakened but may recover and restore their functions. The currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy, but they have a short therapeutic window (4.5 and 6 hours after stroke onset, respectively) and a low percentage of stroke patients actually receive these treatments. Memantine is an approved drug for the treatment of Alzheimer's disease. Memantine is a noncompetitive, low affinity and use-depende

SUBMITTER: MartInez-Coria H 

PROVIDER: S-EPMC7996012 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature