Solid lipid nanoparticles loading with curcumin and dexanabinol to treat major depressive disorder.

ABSTRACT: Dexanabinol (HU-211) is an artificially synthesized cannabinoid derivative that exerts neuroprotective effects through anti-inflammatory and antioxidant effects. Curcumin exhibits antidepressant effects in the treatment of major depressive disorder. To investigate the antidepressant effects of solid lipid nanoparticles loaded with both curcumin and dexanabinol, and the underlying mechanisms associated with this combination, we established wild-type (CBR1^+/+) and cannabinoid receptor 1 (CBR1) knockout (CBR1^-/-) mouse models of major depressive disorder, through the intraperitoneal injection of corticosterone, for 3 successive days, followed by treatment with intraperitoneal injections of solid lipid nanoparticles loading with curcumin (20 mg/kg) and dexanabinol (0.85 m

SUBMITTER: He XL 

PROVIDER: S-EPMC7996013 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature