Epidural electrical stimulation effectively restores locomotion function in rats with complete spinal cord injury.

ABSTRACT: Epidural electrical stimulation can restore limb motor function after spinal cord injury by reactivating the surviving neural circuits. In previous epidural electrical stimulation studies, single electrode sites and continuous tetanic stimulation have often been used. With this stimulation, the body is prone to declines in tolerance and locomotion coordination. In the present study, rat models of complete spinal cord injury were established by vertically cutting the spinal cord at the T8 level to eliminate disturbance from residual nerve fibers, and were then subjected to epidural electrical stimulation. The flexible extradural electrode had good anatomical topology and matched the shape of the spinal canal of the implanted segment. Simultaneously, the electrode stimulation site was able t

SUBMITTER: Wang S 

PROVIDER: S-EPMC7996032 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature