Two predicted models based on ceRNAs and immune cells in lung adenocarcinoma.

ABSTRACT:

Background

It is well accepted that both competitive endogenous RNAs (ceRNAs) and immune microenvironment exert crucial roles in the tumor prognosis. The present study aimed to find prognostic ceRNAs and immune cells in lung adenocarcinoma (LUAD).

Materials and methods

More specifically, we explored the associations of crucial ceRNAs with the immune microenvironment. The Cancer Genome Atlas (TCGA) database was employed to obtain expression profiles of ceRNAs and clinical data. CIBERSORT was utilized to quantify the proportion of 22 immune cells in LUAD.

Results

We constructed two cox regression models based on crucial ceRNAs and immune cells to predict prognosis in LUAD. Subsequently, seven ceRNAs and seven immune cells were involved in prognostic models. We validated

SUBMITTER: Zhang M 

PROVIDER: S-EPMC7996073 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature