Protective Effects of 6,7,4'-Trihydroxyflavanone on Hypoxia-Induced Neurotoxicity by Enhancement of HO-1 through Nrf2 Signaling Pathway.

ABSTRACT: Since hypoxia-induced neurotoxicity is one of the major causes of neurodegenerative disorders, including the Alzheimer's disease, continuous efforts to find a novel antioxidant from natural products are required for public health. 6,7,4'-trihydroxyflavanone (THF), isolated from Dalbergia odorifera, has been shown to inhibit osteoclast formation and have an antibacterial activity. However, no evidence has reported whether THF has a protective role against hypoxia-induced neurotoxicity. In this study, we found that THF is not cytotoxic, but pre-treatment with THF has a cytoprotective effect on CoCl2-induced hypoxia by restoring the expression of anti-apoptotic proteins in SH-SY5y cells. In addition, pre-treatment with THF suppressed CoCl2-induced hypoxia-related genes including HIF1α, p53, V

SUBMITTER: Lee HS 

PROVIDER: S-EPMC7996229 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature