The Two-Component System 09 Regulates Pneumococcal Carbohydrate Metabolism and Capsule Expression.

ABSTRACT: Streptococcus pneumoniae two-component regulatory systems (TCSs) are important systems that perceive and respond to various host environmental stimuli. In this study, we have explored the role of TCS09 on gene expression and phenotypic alterations in S. pneumoniae D39. Our comparative transcriptomic analyses identified 67 differently expressed genes in total. Among those, agaR and the aga operon involved in galactose metabolism showed the highest changes. Intriguingly, the encapsulated and nonencapsulated hk09-mutants showed significant growth defects under nutrient-defined conditions, in particular with galactose as a carbon source. Phenotypic analyses revealed alterations in the morphology of the nonencapsulated hk09- and tcs09-mutants, wh

SUBMITTER: Hirschmann S 

PROVIDER: S-EPMC7996280 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature