Safety Assessment of Bacillus subtilis MB40 for Use in Foods and Dietary Supplements.

ABSTRACT: With the growing popularity of probiotics in dietary supplements, foods, and beverages, it is important to substantiate not only the health benefits and efficacy of unique strains but also safety. In the interest of consumer safety and product transparency, strain identification should include whole-genome sequencing and safety assessment should include genotypic and phenotypic studies. Bacillus subtilis MB40, a unique strain marketed for use in dietary supplements, and food and beverage, was assessed for safety and tolerability across in silico, in vitro, and in vivo studies. MB40 was assessed for the absence of undesirable genetic elements encoding toxins and mobile antibiotic resistance. Tolerability was assessed in both rats and healthy human volunteers. In silico and in vitro t

SUBMITTER: Spears JL 

PROVIDER: S-EPMC7996492 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature