Thinking Outside the Bug: Targeting Outer Membrane Proteins for Burkholderia Vaccines.

ABSTRACT: Increasing antimicrobial resistance due to misuse and overuse of antimicrobials, as well as a lack of new and innovative antibiotics in development has become an alarming global threat. Preventative therapeutics, like vaccines, are combative measures that aim to stop infections at the source, thereby decreasing the overall use of antibiotics. Infections due to Gram-negative pathogens pose a significant treatment challenge because of substantial multidrug resistance that is acquired and spread throughout the bacterial population. Burkholderia spp. are Gram-negative intrinsically resistant bacteria that are responsible for environmental and nosocomial infections. The Burkholderia cepacia complex are respiratory pathogens that primarily infect immunocompromised and cystic fibros

SUBMITTER: Grund ME 

PROVIDER: S-EPMC7996558 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature